IGFBP6 controls the expansion of chemoresistant glioblastoma through paracrine IGF2/IGF-1R signaling

BACKGROUND: Glioblastomas (GBMs), the most common and most lethal of the primary brain tumors, are characterized by marked intra-tumor heterogeneity. Several studies have suggested that within these tumors a restricted population of chemoresistant glioma cells is responsible for recurrence. However,...

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Publicado en:Cell Commun Signal
Autores principales: Oliva, Claudia R., Halloran, Brian, Hjelmeland, Anita B., Vazquez, Ana, Bailey, Shannon M., Sarkaria, Jann N., Griguer, Corinne E.
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6148802/
https://ncbi.nlm.nih.gov/pubmed/30231881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-018-0273-7
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