Functional Characterization of the Promiscuous Prenyltransferase Responsible for Furaquinocin Biosynthesis: IDENTIFICATION OF A PHYSIOLOGICAL POLYKETIDE SUBSTRATE AND ITS PRENYLATED REACTION PRODUCTS

Furaquinocin is a natural polyketide-isoprenoid hybrid (meroterpenoid) that exhibits antitumor activity and is produced by the Streptomyces sp. strain KO-3988. Bioinformatic analysis of furaquinocin biosynthesis has identified Fur7 as a possible prenyltransferase that attaches a geranyl group to an...

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Bibliographic Details
Main Authors: Kumano熊野, Takuto, 匠人, Tomita富田, Takeo, 武郎, Nishiyama西山, Makoto, 真, Kuzuyama葛山, Tomohisa, 智久
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Metabolism
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000947/
https://ncbi.nlm.nih.gov/pubmed/20937800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.153957
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