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Structural basis for the promiscuous biosynthetic prenylation of aromatic natural products

The anti-oxidant naphterpin is a natural product containing a polyketide-based aromatic core with an attached 10-carbon geranyl group derived from isoprenoid (terpene) metabolism1–3. Hybrid natural products such as naphterpin that contain 5-carbon (dimethylallyl), 10-carbon (geranyl) or 15-carbon (f...

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Detalhes bibliográficos
Main Authors: Kuzuyama, Tomohisa, Noel, Joseph P., Richard, Stéphane B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2874460/
https://ncbi.nlm.nih.gov/pubmed/15959519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature03668
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