A new mouse mutant of the Cdh23 gene with early-onset hearing loss facilitates evaluation of otoprotection drugs

We report a novel mutation (erlong, erl) of the cadherin 23 (Cdh23) gene in a mouse model for DFNB12 characterized by progressive hearing loss beginning from post-natal day 27 (P27). Genetic and sequencing analysis revealed a 208T>C transition causing an amino acid substitution (70S-P). Caspase e...

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Hlavní autoři: Han, Fengchan, Yu, Heping, Tian, Cong, Chen, Hui E, Benedict-Alderfer, Cindy, Zheng, Yuxi, Wang, Qiuju, Han, Xu, Zheng, Qing Y
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000876/
https://ncbi.nlm.nih.gov/pubmed/20644563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tpj.2010.60
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