Dual bronchodilatory and pulmonary anti-inflammatory activity of RO5024118, a novel agonist at vasoactive intestinal peptide VPAC(2) receptors

BACKGROUND AND PURPOSE: Vasoactive intestinal peptide is expressed in the respiratory tract and induces its effects via its receptors, VPAC(1) and VPAC(2). RO5024118 is a selective VPAC(2) receptor agonist derived via chemical modification of an earlier VPAC(2) agonist, RO0251553. In the present stu...

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Main Authors: Tannu, SA, Renzetti, LM, Tare, N, Ventre, JD, Lavelle, D, Lin, TA, Morschauser, A, Paciorek, J, Bolin, DR, Michel, H, Singer, L, Hargaden, M, Knowles, ID, Gardiner, P, Cazzola, M, Calzetta, L, Matera, MG, Hicks, A
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 2010
Fag:
Themed Section: Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000657/
https://ncbi.nlm.nih.gov/pubmed/20735404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.00975.x
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