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Tracing entire operation cycles of molecular motor hepatitis C virus helicase in structurally resolved dynamical simulations

Hepatitis C virus helicase is a molecular motor that splits duplex DNA while actively moving over it. An approximate coarse-grained dynamical description of this protein, including its interactions with DNA and ATP, is constructed. Using such a mechanical model, entire operation cycles of an importa...

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Detalhes bibliográficos
Main Authors: Flechsig, Holger, Mikhailov, Alexander S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000295/
https://ncbi.nlm.nih.gov/pubmed/21081697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1014631107
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