MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2)

The overexpression of microRNA-21 (miR-21) is linked to a number of human tumors including colorectal cancer, where it appears to regulate the expression of tumor suppressor genes including p21, phosphatase and tensin homolog, TGFβ receptor II, and B-cell leukemia/lymphoma 2 -associated X protein. H...

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Main Authors: Valeri, Nicola, Gasparini, Pierluigi, Braconi, Chiara, Paone, Alessio, Lovat, Francesca, Fabbri, Muller, Sumani, Khlea M., Alder, Hansjuerg, Amadori, Dino, Patel, Tushar, Nuovo, Gerard J., Fishel, Richard, Croce, Carlo M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2010
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000294/
https://ncbi.nlm.nih.gov/pubmed/21078976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1015541107
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