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Structural basis for substrate activation and regulation by cystathionine beta-synthase (CBS) domains in cystathionine β-synthase

The catalytic potential for H(2)S biogenesis and homocysteine clearance converge at the active site of cystathionine β-synthase (CBS), a pyridoxal phosphate-dependent enzyme. CBS catalyzes β-replacement reactions of either serine or cysteine by homocysteine to give cystathionine and water or H(2)S,...

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Bibliografske podrobnosti
Main Authors: Koutmos, Markos, Kabil, Omer, Smith, Janet L., Banerjee, Ruma
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000283/
https://ncbi.nlm.nih.gov/pubmed/21081698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1011448107
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