Neonatal Diabetes Caused by Mutations in Sulfonylurea Receptor 1: Interplay between Expression and Mg-Nucleotide Gating Defects of ATP-Sensitive Potassium Channels

Context: ATP-sensitive potassium (K(ATP)) channels regulate insulin secretion by coupling glucose metabolism to β-cell membrane potential. Gain-of-function mutations in the sulfonylurea receptor 1 (SUR1) or Kir6.2 channel subunit underlie neonatal diabetes. Objective: The objective of the study was...

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Hlavní autoři: Zhou, Qing, Garin, Intza, Castaño, Luis, Argente, Jesús, Muñoz-Calvo, Ma. Teresa, Perez de Nanclares, Guiomar, Shyng, Show-Ling
Médium: Artigo
Jazyk:Inglês
Vydáno: The Endocrine Society 2010
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2999977/
https://ncbi.nlm.nih.gov/pubmed/20810569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2010-1231
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