Neonatal Diabetes Caused by Mutations in Sulfonylurea Receptor 1: Interplay between Expression and Mg-Nucleotide Gating Defects of ATP-Sensitive Potassium Channels

Context: ATP-sensitive potassium (K(ATP)) channels regulate insulin secretion by coupling glucose metabolism to β-cell membrane potential. Gain-of-function mutations in the sulfonylurea receptor 1 (SUR1) or Kir6.2 channel subunit underlie neonatal diabetes. Objective: The objective of the study was...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Zhou, Qing, Garin, Intza, Castaño, Luis, Argente, Jesús, Muñoz-Calvo, Ma. Teresa, Perez de Nanclares, Guiomar, Shyng, Show-Ling
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2010
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2999977/
https://ncbi.nlm.nih.gov/pubmed/20810569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2010-1231
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados