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The mechanism of retroviral integration through X-ray structures of its key intermediates
To establish successful infection, a retrovirus must insert a DNA replica of its genome into host cell chromosomal DNA1,2. This process is carried out by the intasome, a nucleoprotein complex comprised of a tetramer of integrase (IN) assembled on the viral DNA ends3,4. The intasome engages chromosom...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2999894/ https://ncbi.nlm.nih.gov/pubmed/21068843 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09517 |
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