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Dok1 and Dok2 play opposing roles in CD200R signaling
The CD200 receptor (CD200R) negatively regulates myeloid cells by interacting with its widely expressed ligand CD200. CD200R signals through a unique inhibitory pathway involving a direct interaction with the adaptor protein Dok2 and the subsequent recruitment and activation of RasGAP. Ligand engage...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2999833/ https://ncbi.nlm.nih.gov/pubmed/21078907 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1002858 |
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