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Dok1 and Dok2 play opposing roles in CD200R signaling

The CD200 receptor (CD200R) negatively regulates myeloid cells by interacting with its widely expressed ligand CD200. CD200R signals through a unique inhibitory pathway involving a direct interaction with the adaptor protein Dok2 and the subsequent recruitment and activation of RasGAP. Ligand engage...

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Autors principals: Mihrshahi, Robin, Brown, Marion H.
Format: Artigo
Idioma:Inglês
Publicat: 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2999833/
https://ncbi.nlm.nih.gov/pubmed/21078907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1002858
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