Evaluating plague and smallpox as historical selective pressures for the CCR5-Δ32 HIV-resistance allele
The high frequency, recent origin, and geographic distribution of the CCR5-Δ32 deletion allele together indicate that it has been intensely selected in Europe. Although the allele confers resistance against HIV-1, HIV has not existed in the human population long enough to account for this selective...
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| Опубликовано в:: | Proc Natl Acad Sci U S A |
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| Главные авторы: | , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2003
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC299980/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14645720/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2435085100 |
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