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A combinatorial approach to characterize the substrate specificity of protein arginine methyltransferase 1

The dysregulation of protein arginine methyltransferases (PRMTs) is implicated in a wide variety of disease states. Here we report the design, synthesis, and screening of a combinatorial peptide library used to characterize the substrate specificity of PRMT1. The information gained from this approac...

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Detalhes bibliográficos
Main Authors: Bicker, Kevin L., Obianyo, Obiamaka, Rust, Heather L., Thompson, Paul R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2999663/
https://ncbi.nlm.nih.gov/pubmed/20607165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c0mb00015a
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