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Functional dissection of the alphavirus capsid protease: sequence requirements for activity

BACKGROUND: The alphavirus capsid is multifunctional and plays a key role in the viral life cycle. The nucleocapsid domain is released by the self-cleavage activity of the serine protease domain within the capsid. All alphaviruses analyzed to date show this autocatalytic cleavage. Here we have analy...

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Detalhes bibliográficos
Main Authors: Thomas, Saijo, Rai, Jagdish, John, Lijo, Günther, Stephan, Drosten, Christian, Pützer, Brigitte M, Schaefer, Stephan
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2999604/
https://ncbi.nlm.nih.gov/pubmed/21087473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-7-327
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