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Targeted Disruption of Guanylyl Cyclase-A/Natriuretic Peptide Receptor-A Gene Provokes Renal Fibrosis and Remodeling in Null Mutant Mice: Role of Proinflammatory Cytokines

Binding of atrial and brain natriuretic peptides to guanylyl cyclase-A/natriuretic peptide receptor-A produces second messenger cGMP, which plays an important role in maintaining renal and cardiovascular homeostasis. Mice carrying a targeted disruption of the Npr1 gene coding for guanylyl cyclase-A/...

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Sonraí Bibleagrafaíochta
Main Authors: Das, Subhankar, Au, Edward, Krazit, Stephen T., Pandey, Kailash N.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Endocrine Society 2010
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2999494/
https://ncbi.nlm.nih.gov/pubmed/20881240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2010-0655
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