Estrogen-Induced Apoptosis of Breast Epithelial Cells Is Blocked by NO/cGMP and Mediated by Extranuclear Estrogen Receptors

Estrogen action, via both nuclear and extranuclear estrogen receptors (ERs), induces a variety of cellular signals that are prosurvival or proliferative, whereas nitric oxide (NO) can inhibit apoptosis via caspase S-nitrosylation and via activation of soluble guanylyl cyclase to produce cGMP. The ac...

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Main Authors: Kastrati, Irida, Edirisinghe, Praneeth D., Wijewickrama, Gihani T., Thatcher, Gregory R. J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2999489/
https://ncbi.nlm.nih.gov/pubmed/20943808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2010-0378
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