Amino acid substitutions in the thyroglobulin gene are associated with susceptibility to human and murine autoimmune thyroid disease

The 8q24 locus, which contains the thyroglobulin (Tg) gene, was previously shown to be strongly linked with autoimmune thyroid disease (AITD). We sequenced all 48 exons of the Tg gene and identified 14 single-nucleotide polymorphisms (SNPs). Case control association studies demonstrated that an exon...

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Bibliografiske detaljer
Main Authors: Ban, Yoshiyuki, Greenberg, David A., Concepcion, Erlinda, Skrabanek, Lucy, Villanueva, Ronald, Tomer, Yaron
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC299918/
https://ncbi.nlm.nih.gov/pubmed/14657345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2434175100
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