A glycopeptide in complex with MHC class I uses the GalNAc residue as an anchor

Peptides bind MHC class I molecules by anchoring hydrophobic side chains into pockets in the peptide binding groove. Here, we report an immunogenic (in vitro and in vivo) MUC1 glycopeptide (MUC1–8-5GalNAc) bound to H-2K(b), fully crossreactive with the nonglycosylated variant. Molecular modeling sho...

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Main Authors: Apostolopoulos, Vasso, Yuriev, Elizabeth, Ramsland, Paul A., Halton, Jodie, Osinski, Carla, Li, Wenjun, Plebanski, Magdalena, Paulsen, Hans, McKenzie, Ian F. C.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2003
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC299892/
https://ncbi.nlm.nih.gov/pubmed/14657390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2432220100
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