IDO upregulates regulatory T cells via tryptophan catabolite and suppresses encephalitogenic T cell responses in experimental autoimmune encephalomyelitis

Experimental autoimmune encephalomyelitis (EAE) is a Th1 and Th17 cell-mediated autoimmune disease of the CNS. IDO and tryptophan metabolites have inhibitory effects on Th1 cells in EAE. For Th17 cells, IDO-mediated tryptophan deprivation and small molecule halofuginone-induced amino acid starvation...

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Main Authors: Yan, Yaping, Zhang, Guang-Xian, Gran, Bruno, Fallarino, Francesca, Yu, Shuo, Li, Hongmei, Cullimore, Melissa L., Rostami, Abdolmohamad, Xu, Hui
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998795/
https://ncbi.nlm.nih.gov/pubmed/20944000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1001628
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