Intravenous tolerance effectively overcomes enhanced pro-inflammatory responses and Experimental Autoimmune Encephalomyelitis severity in the absence of IL-12 receptor signaling

Intravenous (i.v.) administration of autoantigen effectively induces Ag-specific tolerance against experimental autoimmune encephalomyelitis (EAE). We and others have shown enhanced EAE severity in mice lacking IL-12 or its receptor, strongly suggesting an immunoregulatory effect of IL-12 signaling....

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Bibliografiske detaljer
Main Authors: Fitzgerald, Denise C., Zhang, Guang-Xian, Yu, Shuo, Cullimore, Melissa L., Zhao, Zhao, Rostami, Abdolmohamad
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351573/
https://ncbi.nlm.nih.gov/pubmed/22522341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2012.03.021
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