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Novel insertion mutation of ABCB1 gene in an ivermectin-sensitive Border Collie
P-glycoprotein (P-gp) is encoded by the ABCB1 gene and acts as an efflux pump for xenobiotics. In the Border Collie, a nonsense mutation caused by a 4-base pair deletion in the ABCB1 gene is associated with a premature stop to P-gp synthesis. In this study, we examined the full-length coding sequenc...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Korean Society of Veterinary Science
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2998746/ https://ncbi.nlm.nih.gov/pubmed/21113104 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4142/jvs.2010.11.4.341 |
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