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Ligand-induced changes in the conformational stability and flexibility of glutamate dehydrogenase and their role in catalysis and regulation

Bovine glutamate dehydrogenase (GDH) is allosterically regulated and requires substrate-induced subunit interactions for maximum catalytic activity. Steady-state and presteady-state kinetics indicate that the rate-limiting step depends on the nature of the substrate and are likely associated with co...

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Bibliografske podrobnosti
Main Authors: Wacker, Sarah A, Bradley, Michael J, Marion, Jimmy, Bell, Ellis
Format: Artigo
Jezik:Inglês
Izdano: Wiley Subscription Services, Inc., A Wiley Company 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998718/
https://ncbi.nlm.nih.gov/pubmed/20665690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.459
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