Environmental Conditions Affect the Kinetics of Nucleation of Amyloid Fibrils and Determine Their Morphology

To understand and tackle amyloid-related diseases, it is crucial to investigate the factors that modulate amyloid formation of proteins. Our previous studies proved that the N47A mutant of the α-spectrin SH3 (Spc-SH3) domain forms amyloid fibrils quickly under mildly acidic conditions. Here, we anal...

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Main Authors: Morel, Bertrand, Varela, Lorena, Azuaga, Ana I., Conejero-Lara, Francisco
格式: Artigo
語言:Inglês
出版: The Biophysical Society 2010
主題:
Protein
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998616/
https://ncbi.nlm.nih.gov/pubmed/21112305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.10.039
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