Calcium-Induced Folding and Stabilization of the Intrinsically Disordered RTX Domain of the CyaA Toxin

The adenylate cyclase toxin (CyaA) is one of the major virulence factors of Bordetella pertussis, the causative agent of whooping cough. Its C-terminal region, the receptor-binding domain (RD), contains ∼40 calcium-binding Repeat in ToXin (RTX) motifs, which are characteristic of many virulence fact...

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Detalhes bibliográficos
Main Authors: Chenal, Alexandre, Karst, Johanna C., Pérez, Ana Cristina Sotomayor, Wozniak, Anna Katarzyna, Baron, Bruno, England, Patrick, Ladant, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2010
Assuntos:
Protein
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998614/
https://ncbi.nlm.nih.gov/pubmed/21112299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.10.016
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