The Akt-inhibitor Erufosine induces apoptotic cell death in prostate cancer cells and increases the short term effects of ionizing radiation

BACKGROUND AND PURPOSE: The phosphatidylinositol-3-kinase (PI3K)/Akt pathway is frequently deregulated in prostate cancer and associated with neoplastic transformation, malignant progression, and enhanced resistance to classical chemotherapy and radiotherapy. Thus, it is a promising target for thera...

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Bibliografiske detaljer
Main Authors: Rudner, Justine, Ruiner, Carola-Ellen, Handrick, René, Eibl, Hans-Jörg, Belka, Claus, Jendrossek, Verena
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2010
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998511/
https://ncbi.nlm.nih.gov/pubmed/21080918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1748-717X-5-108
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