A single-amino-acid substitution in the HA protein changes the replication and pathogenicity of the 2009 pandemic A (H1N1) influenza viruses in vitro and in vivo

BACKGROUND: The novel pandemic A (H1N1) virus was first identified in Mexico in April 2009 and since then it spread world wide over a short period of time. Although the virus infection is generally associated with mild disease and a relatively low mortality, it is projected that mutations in specifi...

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Main Authors: Xu, Lili, Bao, Linlin, Lv, Qi, Deng, Wei, Ma, Yila, Li, Fengdi, Zhan, Lingjun, Zhu, Hua, Ma, Chunmei, Qin, Chuan
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998484/
https://ncbi.nlm.nih.gov/pubmed/21083933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-7-325
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