Multiple phenotypic changes in mice after knockout of the B3gnt5 gene, encoding Lc3 synthase--a key enzyme in lacto-neolacto ganglioside synthesis

BACKGROUND: Ganglioside biosynthesis occurs through a multi-enzymatic pathway which at the lactosylceramide step is branched into several biosynthetic series. Lc3 synthase utilizes a variety of galactose-terminated glycolipids as acceptors by establishing a glycosidic bond in the beta-1,3-linkage to...

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Detalhes bibliográficos
Main Authors: Kuan, Chien-Tsun, Chang, Jinli, Mansson, Jan-Eric, Li, Jianjun, Pegram, Charles, Fredman, Pam, McLendon, Roger E, Bigner, Darell D
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998480/
https://ncbi.nlm.nih.gov/pubmed/21087515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-213X-10-114
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