Preferential megalin-mediated transcytosis of low-hormonogenic thyroglobulin: A control mechanism for thyroid hormone release

Hormone secretion by thyrocytes occurs by fluid phase uptake and lysosomal degradation of the prohormone thyroglobulin (Tg). However, some Tg internalized by megalin bypasses lysosomes and is transcytosed across cells and released into the bloodstream. Because the hormone content of Tg is variable,...

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I whakaputaina i:	Proc Natl Acad Sci U S A
Ngā kaituhi matua:	Lisi, Simonetta, Pinchera, Aldo, McCluskey, Robert T., Willnow, Thomas E., Refetoff, Samuel, Marcocci, Claudio, Vitti, Paolo, Menconi, Francesca, Grasso, Lucia, Luchetti, Fabiana, Collins, A. Bernard, Marinò, Michele
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	National Academy of Sciences 2003
Ngā marau:	Biological Sciences
Urunga tuihono:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC299828/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14657389/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2432267100
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