Smoking-Induced Upregulation of AKR1B10 Expression in the Airway Epithelium of Healthy Individuals

BACKGROUND: The aldo-keto reductase (AKR) gene superfamily codes for monomeric, soluble reduced nicotinamide adenine dinucleotide phosphate-dependent oxidoreductases that mediate elimination reactions. AKR1B10, an AKR that eliminates retinals, has been observed as upregulated in squamous metaplasia...

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Autores principales: Wang, Rui, Wang, Guoqing, Ricard, Megan J., Ferris, Barbara, Strulovici-Barel, Yael, Salit, Jacqueline, Hackett, Neil R., Gudas, Lorraine J., Crystal, Ronald G.
Formato: Artigo
Lenguaje:Inglês
Publicado: American College of Chest Physicians 2010
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Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998206/
https://ncbi.nlm.nih.gov/pubmed/20705797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1378/chest.09-2634
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