MicroRNA (miRNA)-mediated Interaction between Leukemia/Lymphoma-related Factor (LRF) and Alternative Splicing Factor/Splicing Factor 2 (ASF/SF2) Affects Mouse Embryonic Fibroblast Senescence and Apoptosis

Leukemia/lymphoma-related factor (LRF) is a transcriptional repressor, which by recruiting histone deacetylases specifically represses p19/ARF expression, thus behaving as an oncogene. Conversely, in mouse embryonic fibroblasts (MEF), LRF inhibition causes aberrant p19ARF up-regulation resulting in...

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Autori principali: Verduci, Lorena, Simili, Marcella, Rizzo, Milena, Mercatanti, Alberto, Evangelista, Monica, Mariani, Laura, Rainaldi, Giuseppe, Pitto, Letizia
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
Soggetti:
Gene Regulation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998123/
https://ncbi.nlm.nih.gov/pubmed/20923760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.114736
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