Genomics-driven Reconstruction of Acinetobacter NAD Metabolism: INSIGHTS FOR ANTIBACTERIAL TARGET SELECTION

Enzymes involved in the last steps of NAD biogenesis, nicotinate mononucleotide adenylyltransferase (NadD) and NAD synthetase (NadE), are conserved and essential in most bacterial species and are established targets for antibacterial drug development. Our genomics-based reconstruction of NAD metabol...

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Autors principals: Sorci, Leonardo, Blaby, Ian, De Ingeniis, Jessica, Gerdes, Svetlana, Raffaelli, Nadia, de Crécy Lagard, Valérie, Osterman, Andrei
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Metabolism
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998121/
https://ncbi.nlm.nih.gov/pubmed/20926389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.185629
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