Neuronal Inactivation of Peroxisome Proliferator-activated Receptor γ Coactivator 1α (PGC-1α) Protects Mice from Diet-induced Obesity and Leads to Degenerative Lesions

Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is a transcriptional coactivator that regulates diverse aspects of energy metabolism in peripheral tissues. Mice deficient in PGC-1α have elevated metabolic rate and are resistant to diet-induced obesity. However, it remains unknow...

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Detalhes bibliográficos
Main Authors: Ma, Di, Li, Siming, Lucas, Elizabeth K., Cowell, Rita M., Lin, Jiandie D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998117/
https://ncbi.nlm.nih.gov/pubmed/20947495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.151688
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