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The tandem Src homology 2 domain of the Syk kinase: A molecular device that adapts to interphosphotyrosine distances

Conformational flexibility is important for protein function. However, information on the range of conformations accessible to macromolecules in the unbound state is often difficult to obtain. By using the model system of the tandem Src homology 2 domain (i.e., two adjacent Src homology 2 domains) o...

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Detalhes bibliográficos
Main Authors: Kumaran, Sangaralingam, Grucza, Richard A., Waksman, Gabriel
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC299811/
https://ncbi.nlm.nih.gov/pubmed/14657388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2432867100
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