Dipetalodipin, a Novel Multifunctional Salivary Lipocalin That Inhibits Platelet Aggregation, Vasoconstriction, and Angiogenesis through Unique Binding Specificity for TXA(2), PGF(2α), and 15(S)-HETE

Dipetalodipin (DPTL) is an 18 kDa protein cloned from salivary glands of the triatomine Dipetalogaster maxima. DPTL belongs to the lipocalin superfamily and has strong sequence similarity to pallidipin, a salivary inhibitor of collagen-induced platelet aggregation. DPTL expressed in Escherichia coli...

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Detalhes bibliográficos
Main Authors: Assumpção, Teresa C. F., Alvarenga, Patricia H., Ribeiro, José M. C., Andersen, John F., Francischetti, Ivo M. B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998087/
https://ncbi.nlm.nih.gov/pubmed/20889972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.152835
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