Polymorphisms in TBX21 and STAT4 Increase the Risk of Systemic Sclerosis: Evidence of Possible Gene–Gene Interaction and Alterations in Th1/Th2 Cytokines

OBJECTIVE: Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of the skin and internal organs. Dysregulation of the immune system, including the Th1/Th2 cytokine balance, is central to the pathogenesis of SSc. This study was undertaken to investigate the hypothesis that sing...

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Main Authors: Gourh, Pravitt, Agarwal, Sandeep K., Divecha, Dipal, Assassi, Shervin, Paz, Gene, Arora-Singh, Rajpreet K., Reveille, John D., Shete, Sanjay, Mayes, Maureen D., Arnett, Frank C., Tan, Filemon K.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998060/
https://ncbi.nlm.nih.gov/pubmed/19950257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.24958
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