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Myeloperoxidase up-regulates the catalytic activity of inducible nitric oxide synthase by preventing nitric oxide feedback inhibition

Kinetic and structure analysis of inducible nitric oxide synthase (iNOS) revealed that, in addition to the increase of iNOS expression in inflamed areas, the major pathway causing overproduction of NO is destabilization of the iNOS–nitrosyl complex(es) that form during steady-state catalysis. Format...

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Main Authors: Galijasevic, Semira, Saed, Ghassan M., Diamond, Michael P., Abu-Soud, Husam M.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2003
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC299800/
https://ncbi.nlm.nih.gov/pubmed/14657339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2435008100
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