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Internalization of p53(14–29) peptide amphiphiles and subsequent endosomal disruption results in SJSA-1 cell death
In vivo peptide inhibition of tumor suppressor p53 binding to the protein MDM2 is hampered by inefficient delivery of the peptide. Our approach to couple a hydrophobic lipid-like tail on the inhibitory peptide p53(14–29) allowed its intracellular delivery in vitro, in a panel of different cell lines...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2997927/ https://ncbi.nlm.nih.gov/pubmed/20822110 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp100193h |
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