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Structure and Mechanism of ArnA: Conformational Change Implies Ordered Dehydrogenase Mechanism in Key Enzyme for Polymyxin Resistance

The modification of lipid A with 4-amino-4-deoxy-L-arabinose (Ara4N) allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin. ArnA is the first enzyme specific to the lipid A-Ara4N pathway. It contains two functionally a...

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Detalhes bibliográficos
Main Authors: Gatzeva-Topalova, Petia Z., May, Andrew P., Sousa, Marcelo C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2997725/
https://ncbi.nlm.nih.gov/pubmed/15939024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2005.03.018
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