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Acyl-CoA Binding Protein Gene Ablation Induces Pre-implantation Embryonic Lethality in Mice

Unique among the intracellular lipid binding proteins, acyl-CoA binding protein (ACBP) exclusively binds long-chain fatty acyl-CoAs (LCFA-CoAs). To test if ACBP is an essential protein in mammals, the ACBP gene was ablated by homologous recombination in mice. While ACBP heterozygotes appeared phenot...

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Hlavní autoři: Landrock, Danilo, Atshaves, Barbara P., McIntosh, Avery L., Landrock, Kerstin K., Schroeder, Friedhelm, Kier, Ann B.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2997683/
https://ncbi.nlm.nih.gov/pubmed/20559753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11745-010-3437-9
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