Spectroscopic and computational investigation of three Cys-to-Ser mutants of nickel superoxide dismutase: insight into the roles played by the Cys2 and Cys6 active-site residues

Nickel-dependent superoxide dismutase (Ni-SOD) is a member of a class of metalloenzymes that protect aerobic organisms from the damaging superoxide radical (O(2)(·−)). A distinctive and fascinating feature of NiSOD is the presence of active-site nickel–thiolate interactions involving the Cys2 and Cy...

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Bibliographic Details
Main Authors: Johnson, Olivia E., Ryan, Kelly C., Maroney, Michael J., Brunold, Thomas C.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2997571/
https://ncbi.nlm.nih.gov/pubmed/20333422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00775-010-0641-2
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