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Fluid Shear Stress Induces Renal Epithelial Gene Expression through Polycystin-2-Dependent Trafficking of Extracellular Regulated Kinase
BACKGROUND: The cilium and cilial proteins have emerged as principal mechanosensors of renal epithelial cells responsible for translating mechanical forces into intracellular signals. Polycystin-2 (PC-2), a cilial protein, regulates flow/shear-induced changes in intracellular Ca(2+) ([Ca(2+)](i)) an...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
S. Karger AG
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2997441/ https://ncbi.nlm.nih.gov/pubmed/21109758 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000321640 |
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