Influence of an Additional Amino Group on the Potency of Aminoadamantanes Against Influenza Virus A. II – Synthesis of Spiropiperazines and In-Vitro Activity Against Influenza A H3N2 Virus

Spiro[piperidine-2,2′-adamantane] 4 is one of the most potent synthetic anti-influenza A aminoadamantanes or other cage structure amines tested so far. Based on previous results(5h) which demonstrate the boost of in-vitro potency by the presence of an additional amino group, we examined whether the...

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Hauptverfasser: Fytas, Christos, Kolocouris, Antonios, Fytas, George, Grigoris, Zoidis, Valmas, Charalambos, Basler, Christopher F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2997423/
https://ncbi.nlm.nih.gov/pubmed/20926112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bioorg.2010.09.001
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