RAS gene mutations in acute and chronic myelocytic leukemias, chronic myeloproliferative disorders, and myelodysplastic syndromes.

We report on investigations aimed at detecting mutated RAS genes in a variety of preleukemic disorders and leukemias of myeloid origin. DNA transfection analyses (tumorigenicity assay) and hybridization to mutation-specific oligonucleotide probes established NRAS mutations in codon 12 or 61 of 4/9 a...

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Bibliografiske detaljer

Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	Janssen, J W, Steenvoorden, A C, Lyons, J, Anger, B, Böhlke, J U, Bos, J L, Seliger, H, Bartram, C R
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 1987
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC299726/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3122217/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.24.9228
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