TNFα and IFNγ contribute to F1/LcrV-targeted immune defense in mouse models of fully virulent pneumonic plague

Immunization with the Yersinia pestis F1 and LcrV proteins improves survival in mouse and non-human primate models of pneumonic plague. F1- and LcrV-specific antibodies contribute to protection, however, the mechanisms of antibody-mediated defense are incompletely understood and serum antibody titer...

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Main Authors: Lin, Jr-Shiuan, Park, Steven, Adamovicz, Jeffrey J., Hill, Jim, Bliska, James B., Cote, Christopher K., Perlin, David S., Amemiya, Kei, Smiley, Stephen T.
Format: Artigo
Language:Inglês
Published: 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2997115/
https://ncbi.nlm.nih.gov/pubmed/20840834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2010.08.099
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