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Redox Sensitive Calcium Stores Underlie Enhanced After Hyperpolarization of Aged Neurons: Role for Ryanodine Receptor Mediated Calcium Signaling

A decrease in the excitability of CA1 pyramidal neurons contributes to the age related decrease in hippocampal function and memory decline. Decreased neuronal excitability in aged neurons can be observed as an increase in the Ca(2+)- activated K(+)- mediated post burst afterhyperpolarization (AHP)....

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Autors principals: Bodhinathan, Karthik, Kumar, Ashok, Foster, Thomas C.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2997029/
https://ncbi.nlm.nih.gov/pubmed/20884759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.00577.2010
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