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RNA polymerase mutants found through adaptive evolution reprogram Escherichia coli for optimal growth in minimal media
Specific small deletions within the rpoC gene encoding the β′-subunit of RNA polymerase (RNAP) are found repeatedly after adaptation of Escherichia coli K-12 MG1655 to growth in minimal media. Here we present a multiscale analysis of these mutations. At the physiological level, the mutants grow 60%...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2996682/ https://ncbi.nlm.nih.gov/pubmed/21057108 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911253107 |
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