Trapping of palindromic ligands within native transthyretin prevents amyloid formation

Transthyretin (TTR) amyloidosis is a fatal disease for which new therapeutic approaches are urgently needed. We have designed two palindromic ligands, 2,2'-(4,4'-(heptane-1,7-diylbis(oxy))bis(3,5-dichloro-4,1-phenylene)) bis(azanediyl)dibenzoic acid (mds84) and 2,2'-(4,4'-(undeca...

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Detalhes bibliográficos
Main Authors: Kolstoe, Simon E., Mangione, Palma P., Bellotti, Vittorio, Taylor, Graham W., Tennent, Glenys A., Deroo, Stéphanie, Morrison, Angus J., Cobb, Alexander J. A., Coyne, Anthony, McCammon, Margaret G., Warner, Timothy D., Mitchell, Jane, Gill, Raj, Smith, Martin D., Ley, Steven V., Robinson, Carol V., Wood, Stephen P., Pepys, Mark B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996680/
https://ncbi.nlm.nih.gov/pubmed/21059958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1008255107
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