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Detoxifying carcinogenic polyhalogenated quinones by hydroxamic acids via an unusual double Lossen rearrangement mechanism

Hydroxamic acids, which are best-known for their metal-chelating properties in biomedical research, have been found to effectively detoxify the carcinogenic polyhalogenated quinoid metabolites of pentachlorophenol and other persistent organic pollutants. However, the chemical mechanism underlying su...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zhu, Ben-Zhan, Zhu, Jun-Ge, Mao, Li, Kalyanaraman, Balaraman, Shan, Guo-Qiang
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996439/
https://ncbi.nlm.nih.gov/pubmed/21076034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1010950107
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